A joint research team with scientists from the CAS developed the tumor-targeting nanoparticles as a combination of tumor-inrction therapy and chemotherapy, said the CAS.
Chinese researchers have developed biodegradable tumor-targeting nanoparticles, which provides a promising therapy for tumor treatment, according to the Chinese Academy of Sciences (CAS).
The study has been published online by the journal Nature Biomedical Engineering.
Study results showed that the co-administration of a cytotoxic payload and a protease to elicit vascular inrction in tumors with biodegradable tumor-targeting nanoparticles represented a promising strategy for improving the therapeutic index of coagulation-based tumor therapy.
It has long been a challenge for researchers to find a safe and effective therapy for vascular thrombosis. Drugs that induce thrombosis in the tumor vasculature have not resulted in long-term tumor eradication.
The CAS research team developed the nanoparticle, a type of DNA nanorobot that can precisely send the thrombin to the tumor-vessel walls and the tumor stroma, leaving the tumor to starve to death.